The ME's report also has a note at the end. She suspects poisoning based on the below results.

 

Metabolite

Level Compared to Normal (High, Normal, or Low)

Oxygen

High

NADH

High

NAD+

Low

Pyruvate

Normal

Glucose

Normal

Acetyl CoA

Normal

ATP

Low

ADP

High

 

1.     What is the role of each of the above metabolites in cellular respiration?

 

2.     Which of the above are abnormal? Which are normal?

 

3.     Based on your answers to the first two questions, what part of cellular respiration do you believe was interrupted?

 

Part IV: Test Results

The ME received results for three poisons, and one came back positive: cyanide, a potent inhibitor of cellular respiration.

 

1.     What is the mechanism of action of cyanide? Focus on the enzyme it inhibits, the type of inhibition, and the normal role of the enzyme in cellular respiration.

 

2. Explain how Meleea died of asphyxiation when her oxygen levels are high.

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