Look at the following amino-acid sequences from two warm-water species and one cold-water species and identify where changes in the sequence occurred. Line 1: C. punctipinnis:Temperate (cold-adapted) Line 2: C. caudalis:Tropical(warm-adapted) Line 3: C. xanthochira: Tropical (warm-adapted) 151 GFERHRVIGS GTNLDSARFR HIMGEKLHLH PSSCHGWIVG EHDGSSVPVW GFERHRVIGS GTNLDSARFR HIMGEKLHLH PSSCHGWIVG EHDGSSVPVW GFERHRVIGS GTNLDSARFR HIMGEKLHLH PSSCHGWIIG EHDGSSVPVW 201 SGVNVAGVSL QGLNPQMGTD GDSEKWKEVH KLVVDGAYEV IKLKGYTSWA SGVNVAGVSL QALNPQMGAE GDSENWKAVH KQVVDGAYEV IKLKGYTSWA SGVNVAGVSL QGLNPKMGAE GDSENWKEVH KLVVDGAYEV IKLKGYTSWA 251 IGMSVADLVE SIMKNLHKVH PVSTLVQGMH GVKDEVFLSV PCVLGNSGLT IGMSVADLVE SIMKNLHKVH PVSTLVQGMH GVKDEVFLSV PCVLGNSGLT IGMSVADLVE SIMKNLHKVH PVSTLVQGMH GVKDEVFLSV PCVLGNSGLT 301 DVIHMTLKPE EEKQLVKSAE TLWGVQKELT DVIHMTLKPD EEKVLVKSAE TLWGVQKELT DVIHMTLKPD EEKQLVKSAE TLWGVQKELT

Which amino acids changed between the three species? List four of them below, using the number of the amino acid. Example: Amino acid 189 changed from valine to isoleucine in a warm adapted species.

1) __________________

r.

1) _______________________________________________________________

2) _______________________________________________________________

3) _______________________________________________________________

4) _______________________________________________________________

 

How might the changes that you identified affect the protein’s structure

_____________________________________________

2) _______________________________________________________________

3) _______________________________________________________________

4) _______________________________________________________________

 

What were the changes in the chemical properties of the R-groups? Use the amino-acid chart to in the Powerpoint file to answer this question. Example: Both valine and isoleucine are nonpola? Example: The change would likely have no effect. Neither valine and isoleucine would promote hydrogen bonding with water, because their R groups are nonpolar and thus hydrophobic.

1) _______________________________________________________________

2) _______________________________________________________________

3) _______________________________________________________________

4) _______________________________________________________________

 

4. Assuming that the mutations are adaptive, how should the changes that you identified affect the stability of the protein at low and high temperatures?

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