Levels Tought:
Elementary,Middle School,High School,College,University,PHD
Teaching Since: | Apr 2017 |
Last Sign in: | 229 Weeks Ago, 6 Days Ago |
Questions Answered: | 12843 |
Tutorials Posted: | 12834 |
MBA, Ph.D in Management
Harvard university
Feb-1997 - Aug-2003
Professor
Strayer University
Jan-2007 - Present
1. In the bioeynthesis of cytidine triphoaphate, sphnspnmisnsyr risphoapt'rate {PRPP} reacts with
el'otete to give the rbonucleotide oretidine rrronophospahte {DHP} as shown behw. The
ribonuceotitte formation takes place by a nucleophilc substimtion reaction cetaiyzett by the
enzyme orotate phosphorhosylltansferase. [1D pts] sis Hijfi'tfi/ et—
5 s“ tr mm“ For? ”HP
:3} In the first step of this reaction FRFP generates a resonance stabilized carbocation. Using
curried arrows propose a mechanism hetow tor the formation of this carbocation and provide a resonance structure aiso using arrows to show the new of electrons in its torrnetion.
3} ‘D-F—CI
I o “i spines ” / O carbocafion b} Using owed arrows, propose a mechanism below for the DRIP-forming reaction of the
carbonation above 1ilr'ith orotate. Note that: the enzyme p-I'e'tiltt-ee e hose {:5} that to useful here.
o b}
-----------