THE EUKARYOTIC CELL CYCLE AND CANCER: AN OVERVIEW ABOUT THIS WORKSHEET
This worksheet complements the Click and Learn “The Eukaryotic Cell Cycle and Cancer” and is
intended as a straightforward introduction to the cell cycle and how that relates to cancer. For a more
comprehensive student worksheet, please see the in depth version.
PROCEDURE
Read through the Click and Learn at (http://www.hhmi.org/biointeractive/eukaryotic-cell-cycle-andcancer) to learn about the cell cycle. Answer the questions below. Click on the “Background” tab on the right side. Read the information and watch the videos.
1. Why is cell division important for both unicellular and multicellular organisms? 2. Why does cell division remain important to an adult organism even after it is fully developed? 3. Cells divide, differentiate, or die. What is differentiation? 4. What is apoptosis? What is its purpose? 5. What are cell cycle regulators? 6. What happens if cell cycle regulators don’t function properly? www.BioInteractive.org Published February 2016 Page 1 of 4 Click on the purple section labeled “Cell Cycle Phases” as well as the words “Mitosis” and
“Interphase” to read an overview of the cell cycle. You can also click on the various phases.
7. Cells go through periods of growth and division. Cell division occurs during _______________.
8. The rest of the cell cycle is called interphase, during which _____________________________
_____________________________________________________________________________. 9. Fill in the details about what happens during the three phases of interphase labeled in the
diagram. 10. In general, what is the purpose of a checkpoint in the cell cycle? www.BioInteractive.org Published February 2016 Page 2 of 4 11. What is the G0 phase of the cell cycle? Which factors determine whether a cell enters G0? Can cells leave G0? Click on “Cell Cycle Regulators and Cancer” in the center purple circle. Read the Regulators
Overview and then read through the Cancer Overview and watch the videos.
12. What are cell cycle regulators? a. Stimulatory proteins are encoded by _________________________________.
Examples include: ______________________________________________________
b. Inhibitory proteins are encoded by ___________________________________________.
Examples include: ______________________________________________________ 13. Cancer is the result of an improperly regulated cell cycle. Describe two reasons why cells can form
tumors. 14. In some types of colon cancer, stem cells have a mutation in the APC gene. What happens if the
APC gene is mutated? 15. Normally, proto-oncogenes stimulate the cell cycle. What are oncogenes and how do they affect
the cell cycle? www.BioInteractive.org Published February 2016 Page 3 of 4 a. To cause cancer, proto-oncogenes require _________ allele(s) to be mutated and
therefore are considered ____________________. The mutation results in a __________ of
function. 16. Normally, tumor suppressor genes inhibit the cell cycle. How do mutated tumor suppressor genes
affect the cell cycle? a. To cause cancer, tumor suppressor genes require _________ allele(s) to be mutated and
therefore are considered ____________________. The mutation results in a __________ of
function. www.BioInteractive.org Published February 2016 Page 4 of 4

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