Most kids with sickle cell disease have some degree of anemia and might develop one or more of the following conditions and symptoms as part of the disorder:

Acute chest syndrome: Inflammation, infection, and occlusion (blockages) of small vessels of the lung may cause this syndrome. Signs include chest pain, coughing, difficulty breathing, and fever.

Aplastic crisis: This is when the bone marrow temporarily slows its production of RBCs due to infection (most commonly parvovirus) or another cause, resulting in a serious drop in RBCs and severe anemia. Signs include paleness, fatigue, and rapid pulse.

Hand-foot syndrome (also called dactylitis): This painful swelling of the hands and feet may be the first sign of sickle cell anemia in some infants.

Infection: Kids with sickle cell disease are at increased risk for certain bacterial infections. It's important to watch for fevers of 101°F (38°C) or higher, which could signal an infection. Children with sickle cell disease and a fever should be seen by a doctor immediately.

Painful crises: These may happen in any part of the body and may be brought on by cold, stress, or dehydration. The pain may last a few hours, a few days, or sometimes much longer. Pain may be so severe that a child needs to be hospitalized.

Splenic sequestration crises: The spleen becomes enlarged by trapping (or "sequestering") the abnormal RBCs. This can lead to a serious and rapid drop in the red cell count (severe anemia). Early signs include paleness, weakness or fatigue, an enlarged spleen, and pain in the abdomen.

Stroke: Impaired blood flow in the brain can happen when the sickle-shaped cells block small blood vessels, which may lead to a stroke. Signs can include headache, seizures, weakness of the arms and legs, speech problems, a facial droop, or loss of consciousness.

Other possible complications include leg ulcers, bone or joint damage, gallstones, kidney damage, painful prolonged erections in males (priapism), eye damage, and delayed growth.

 

 

Miller, R. (2015). Sickle Cell Disease. Retrieved April 23, 2017. http://kidshealth.org/en/parents/sickle-cell-anemia.html#

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