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| Teaching Since: | May 2017 |
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MCS,PHD
Argosy University/ Phoniex University/
Nov-2005 - Oct-2011
Professor
Phoniex University
Oct-2001 - Nov-2016
6. What is the quasi-likelihood approach for extending the logistic regression model to account for a case in which more variation appears than was predicted by the binomial distribution?
7. Malformed Forelimbs. In a randomized experiment, mouse fetuses were injected with 500, 750, or 1,000 mg/kg of acetazolamide on day 9 of gestation. (Data from L. B. Holmes, H. Kawanishi, and A. Munoz, “Acetazolamide: Maternal Toxicity, Pattern of Malformations, and Litter Effect,” Teratology 37 (1988): 335–42.) On day 18 of gestation, the fetus was removed and examined for malformations in the front legs. Display 21.17 shows the results. (a) Suppose that the response
variable for each mouse fetus is the number of forelimbs with malformations. Explain how logistic regression can be used to study the relationship between malformation probability and dose. (b) What is the sample size? (c) Is it necessary to worry about extra-binomial variation? (d) Is it appropriate to use the deviance goodness-of-fit test for model checking? (e) Is it appropriate to obtain a confidence interval for the effect of dose? (f) How would the resulting confidence interval be used in a sentence summarizing the statistical analysis?

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