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Category > Biology Posted 09 Jun 2017 My Price 4.00

African Americans

A type of end-stage kidney disease is relatively common among African Americans that is very rare among other groups of people Two mutant recessive alleles, G1 and G2, in the ApoL1 gene on chromosome 22 cause the condition. Individuals who are G1G1, G2G2 or G1G2 are likely to get the disorder. Individuals who have neither mutant allele or have only one copy of one of them usually do not get the disease.

Studies have shown that the presence of one or two copies of these mutant alleles protects individuals against the parasite, Trypanosoma brucei, which causes African sleeping sickness, a serious disease in Africa. Why is the frequency of the G1 and G2 mutant alleles so high among African Americans when they often lead to a terminal kidney condition when homozygous? What type of selection seems to be involved here? Why?   

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Status NEW Posted 09 Jun 2017 06:06 AM My Price 4.00

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