A 3-year-old Afro-Caribbean girl presents with severe pain in her hands and abdomen. On examination there is mucosal pallor, yellow sclera, generalized abdominal tenderness with hepatosplenomegaly. Blood samples were taken including a CBC: Hb 6.1mg/dl, MCV 78fl, WBC 6000/cu.mm, platelets 300,000 / cu.mm.

Q. What is the initial impression of the case?

 

 

Q. What is the genetic defect of her blood?

 

 

Q. What causes the pain symptoms in this child?

 

 

Q. What is yellow sclera referred to as?

 

 

Q. What is the name of the clinical condition of this child?

 

 

Q. Why she developed hepatosplenomegaly?

 

 

Q. Write the words for the following abbreviations: CBC, HB, MCV, WBC,

 

 

 

Q. Give the normal numeric values of the following

Hb,                             MCV,                         MCH (or Hct),                                  Platelets

RBCs                          WBCs                                                

 

Q. What does the blood CBC finding shows for Hb?

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